In which condition would you see fibrinoid necrotizing arteritis?

Fibrinoid necrotizing arteritis is most commonly associated with polyarteritis nodosa, a type of medium vessel vasculitis. This condition involves systemic inflammation of the medium-sized muscular arteries, leading to transmural inflammation and fibrin deposition in the vessel walls. The histopathological findings in polyarteritis nodosa typically reveal fibrinogen and other plasma proteins accumulating in the arterial wall, leading to a characteristic "fibrinoid necrosis" appearance. This results in mural necrosis, which can contribute to potential aneurysm formation or luminal narrowing.

Polyarteritis nodosa can present with a variety of clinical symptoms due to the effect of the vasculitis on different organ systems; it particularly affects the kidneys, skin, and nervous system. The presence of systemic symptoms like fever, malaise, and weight loss may accompany these organ-specific manifestations.

In contrast, other conditions listed have different pathophysiological mechanisms and histological findings. For example, systemic sclerosis is primarily associated with fibrosis and vascular dysregulation rather than fibrinoid necrosis. Granulomatosis with polyangiitis and Wegener’s granulomatosis (now referred to simply as granulomatosis with polyangiitis) typically involve