What is the mechanism of action of albendazole and mebendazole?

Albendazole and mebendazole are both benzimidazole anthelmintic drugs primarily used to treat parasitic worm infections. Their mechanism of action primarily involves the inhibition of microtubule synthesis.

These drugs bind to β-tubulin, resulting in the destabilization and disruption of microtubule formation. This impairment prevents the effective assembly of microtubules, which are essential for various cellular functions, including the transport processes within the parasite's cells. The disruption of microtubule formation ultimately leads to reduced motility, impaired nutrient absorption, and can result in the death of the parasites.

Understanding this action provides insights into why these medications are effective against a variety of nematodes and some cestode infections, as parasites rely heavily on microtubules for their survival and reproduction.