Which drug enhances the effect of prazosin?

Prazosin is an alpha-1 adrenergic antagonist primarily used to treat hypertension and symptoms of benign prostatic hyperplasia. By blocking alpha-1 receptors, prazosin leads to vasodilation and a decrease in blood pressure.

Epinephrine enhances the effects of prazosin because it acts as a non-selective adrenergic agonist. While prazosin blocks alpha-1 adrenergic receptors, epinephrine activates both alpha and beta-adrenergic receptors. In particular, the beta-2 adrenergic receptor activation by epinephrine leads to vasodilation, potentially countering the action of alpha-1 effects. However, when considering the impact on the cardiovascular system, epinephrine could lead to increased cardiac output and potentially greater downstream effects on blood pressure regulation, enhancing the overall therapeutic effects provided by prazosin.

In contrast, drugs like atropine, which is an anticholinergic agent, and propranolol, a beta-blocker, do not work synergistically with prazosin to enhance its effectiveness. They would have different mechanisms of action that do not complement the effects of alpha-1 blockade. Ephedrine, a mixed-action sympathomimetic, would not necessarily enhance pr